CMap Candidate Details

Structure:
CMap ID: C33463
Pert ID: BRD-K98004573
Compound Name: rupatadine
Targets: HRH1; PTAFR
MoA: Histamine receptor antagonist; Platelet activating factor receptor antagonist
SMILES: Cc1cncc(CN2CCC(CC2)=C2c3ccc(Cl)cc3CCc3cccnc23)c1
InchiKey: WUZYKBABMWJHDL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128123 BRD-K98004573 A375 10 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
128154 BRD-K98004573 A549 0.125 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.2
128194 BRD-K98004573 HT29 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
128247 BRD-K98004573 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128274 BRD-K98004573 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128326 BRD-K98004573 MDAMB231 3.33 uM 24 h 0.32 1.35 0.93 -0.24 -0.82 0.15
128342 BRD-K98004573 PC3 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.77
128366 BRD-K98004573 THP1 10 uM 24 h 0.25 1.05 0.17 -0.27 -0.91 0.31
135831 BRD-K98004573 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135869 BRD-K98004573 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135921 BRD-K98004573 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
136011 BRD-K98004573 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136157 BRD-K98004573 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).