CMap Candidate Details

Structure:
CMap ID: C33502
Pert ID: BRD-K98143437
Compound Name: SB-239063
Targets: MAPK14; MAPK11
MoA: P38 MAPK inhibitor
SMILES: COc1nccc(n1)c2c(ncn2C3CCC(O)CC3)c4ccc(F)cc4
InchiKey: ZQUSFAUAYSEREK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2954 BRD-K98143437 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
3306 BRD-K98143437 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3915 BRD-K98143437 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.22
39540 BRD-K98143437 A549 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
40156 BRD-K98143437 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41633 BRD-K98143437 SKB 10 uM 24 h 0.23 0.97 0.08 0.34 1.2 1.07
94424 BRD-K98143437 A375 1.11 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
94493 BRD-K98143437 ASC 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
94566 BRD-K98143437 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94654 BRD-K98143437 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94704 BRD-K98143437 HELA 1.11 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
94761 BRD-K98143437 HME1 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
94802 BRD-K98143437 HT29 1.11 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
94853 BRD-K98143437 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
94903 BRD-K98143437 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
94949 BRD-K98143437 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94985 BRD-K98143437 MCF??7.00 1.11 uM 24 h -0.28 -1.15 0.44 -0.23 -0.76 0.08
95031 BRD-K98143437 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
95058 BRD-K98143437 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95128 BRD-K98143437 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95179 BRD-K98143437 SHSY5Y 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95242 BRD-K98143437 SKL 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
95288 BRD-K98143437 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).