CMap Candidate Details

Structure:
CMap ID: C33528
Pert ID: BRD-K98203492
Compound Name: GSK-J4
Targets: KDM6B; KDM6A
MoA: Histone lysine demethylase inhibitor
SMILES: CCOC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
InchiKey: WBKCKEHGXNWYMO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93648 BRD-K98203492 ASC 0.04 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
93707 BRD-K98203492 CD34 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
93753 BRD-K98203492 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93834 BRD-K98203492 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93881 BRD-K98203492 HELA 0.04 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
93922 BRD-K98203492 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93988 BRD-K98203492 HUVEC 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
94018 BRD-K98203492 JURKAT 10 uM 24 h -0.29 -1.21 0.57 0.0 0.0 0.0
94058 BRD-K98203492 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
94099 BRD-K98203492 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
94172 BRD-K98203492 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94232 BRD-K98203492 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
94283 BRD-K98203492 SKL 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94332 BRD-K98203492 THP1 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95946 BRD-K98203492 YAPC 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97023 BRD-K98203492 A375 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
97101 BRD-K98203492 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117045 BRD-K98203492 A549 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
117123 BRD-K98203492 HCC515 10 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
117219 BRD-K98203492 HT29 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.97
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).