CMap Candidate Details

Structure:
CMap ID: C03357
Pert ID: BRD-K02965346
Compound Name: SU-11274
Targets: MET
MoA: Tyrosine kinase inhibitor; Hepatocyte growth factor receptor inhibitor
SMILES: CN(c1cccc(Cl)c1)S(=O)(=O)c1ccc2NC(=O)C(=C/c3[nH]c(C)c(C(=O)N4CCN(C)CC4)c3C)c2c1
InchiKey: FPYJSJDOHRDAMT-KQWNVCNZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33681 BRD-K02965346 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34028 BRD-K02965346 ASC 10 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
34542 BRD-K02965346 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34811 BRD-K02965346 HEPG2 10 uM 6 h 0.24 1.0 0.11 0.33 1.18 1.0
35716 BRD-K02965346 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35924 BRD-K02965346 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36184 BRD-K02965346 PHH 10 uM 24 h 0.22 0.94 0.05 0.19 0.68 0.01
36477 BRD-K02965346 SKB 10 uM 24 h 0.0 0.0 0.0 0.46 1.61 2.39
36763 BRD-K02965346 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92023 BRD-K02965346 BT20 10 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
92072 BRD-K02965346 HA1E 10 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
92161 BRD-K02965346 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92192 BRD-K02965346 HT29 3.33 uM 24 h 0.3 1.23 0.5 -0.26 -0.88 0.25
92217 BRD-K02965346 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
92258 BRD-K02965346 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92292 BRD-K02965346 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
92371 BRD-K02965346 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96103 BRD-K02965346 A549 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).