CMap Candidate Details

Structure:
CMap ID: C33683
Pert ID: BRD-K98769987
Compound Name: flumazenil
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ
MoA: Benzodiazepine receptor antagonist
SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
InchiKey: OFBIFZUFASYYRE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3421 BRD-K98769987 HCC515 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.23
25460 BRD-K98769987 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41859 BRD-K98769987 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42503 BRD-K98769987 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42812 BRD-K98769987 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
43677 BRD-K98769987 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44225 BRD-K98769987 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90930 BRD-K98769987 HUH7 10 uM 72 h 0.0 0.0 0.0 0.27 0.95 0.31
127794 BRD-K98769987 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127877 BRD-K98769987 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127951 BRD-K98769987 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128003 BRD-K98769987 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135529 BRD-K98769987 HA1E 2.22 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
135578 BRD-K98769987 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135620 BRD-K98769987 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135669 BRD-K98769987 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.04
135701 BRD-K98769987 MCF??7.00 2.22 uM 24 h -0.16 -0.66 0.0 0.0 0.0 0.0
135725 BRD-K98769987 PC3 0.74 uM 24 h 0.22 0.93 0.05 0.2 0.71 0.02
135748 BRD-K98769987 YAPC 0.03 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).