CMap Candidate Details

Structure:
CMap ID: C33820
Pert ID: BRD-K99257182
Compound Name: quinine
Targets: KCNN4
MoA: Hemozoin biocrystallization inhibitor
SMILES: COc1ccc2nccc([C@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
InchiKey: LOUPRKONTZGTKE-FEBSWUBLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127759 BRD-K99257182 A375 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
127803 BRD-K99257182 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 1.0
127888 BRD-K99257182 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127962 BRD-K99257182 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
128012 BRD-K99257182 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128059 BRD-K99257182 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135534 BRD-K99257182 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.07
135588 BRD-K99257182 HELA 2.22 uM 24 h 0.33 1.37 0.97 -0.18 -0.6 0.0
135626 BRD-K99257182 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135680 BRD-K99257182 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135707 BRD-K99257182 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135751 BRD-K99257182 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).