CMap Candidate Details

Structure:
CMap ID: C33826
Pert ID: BRD-K99291625
Compound Name: SB-203580
Targets: MAPK14; MAPK11
MoA: P38 MAPK inhibitor
SMILES: CS(=O)(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4
InchiKey: XEOVWJYINDYNSM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33669 BRD-K99291625 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33863 BRD-K99291625 A549 10 uM 24 h 0.25 1.03 0.13 0.2 0.7 0.02
34221 BRD-K99291625 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34455 BRD-K99291625 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34723 BRD-K99291625 HCC515 10 uM 6 h 0.24 1.01 0.12 -0.33 -1.12 0.93
35001 BRD-K99291625 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35236 BRD-K99291625 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35361 BRD-K99291625 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35645 BRD-K99291625 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
35876 BRD-K99291625 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36017 BRD-K99291625 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36392 BRD-K99291625 PHH 10 uM 24 h 0.24 1.0 0.11 -0.32 -1.08 0.79
36692 BRD-K99291625 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36904 BRD-K99291625 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).