CMap Candidate Details

Structure:
CMap ID: C33852
Pert ID: BRD-K99369265
Compound Name: sirolimus
Targets: FKBP1A; MTOR
MoA: MTOR inhibitor
SMILES: CC[C@@H]1C=C(C)/C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(C)=C[C@@H]1CC[C@@H](O)[C@@H](C1)OC
InchiKey: ZDQSOHOQTUFQEM-NURRSENYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33544 BRD-K99369265 A375 10 uM 6 h -0.24 -1.0 0.15 -0.33 -1.11 0.91
33864 BRD-K99369265 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34222 BRD-K99369265 ASC 10 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
34456 BRD-K99369265 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.06
34724 BRD-K99369265 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35002 BRD-K99369265 HEPG2 10 uM 6 h 0.21 0.86 0.01 -0.2 -0.66 0.01
35237 BRD-K99369265 HT29 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.26
35386 BRD-K99369265 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35646 BRD-K99369265 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35877 BRD-K99369265 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
36119 BRD-K99369265 PC3 10 uM 6 h -0.3 -1.26 0.71 -0.31 -1.04 0.67
36393 BRD-K99369265 PHH 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
36693 BRD-K99369265 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36905 BRD-K99369265 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).