CMap Candidate Details

Structure:
CMap ID: C33859
Pert ID: BRD-K99383816
Compound Name: ftorafur
Targets: TYMS
MoA: Thymidylate synthase inhibitor
SMILES: Fc1cn([C@H]2CCCO2)c(=O)[nH]c1=O
InchiKey: WFWLQNSHRPWKFK-ZCFIWIBFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95672 BRD-K99383816 U2OS 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
96315 BRD-K99383816 A375 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
96386 BRD-K99383816 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127800 BRD-K99383816 A549 1.11 uM 24 h -0.23 -0.94 0.08 0.26 0.91 0.24
127885 BRD-K99383816 HEK293 0.04 uM 24 h 0.23 0.96 0.08 -0.26 -0.87 0.23
127907 BRD-K99383816 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127959 BRD-K99383816 HUVEC 10 uM 24 h 0.28 1.15 0.34 0.27 0.96 0.34
128009 BRD-K99383816 MCF10A 10 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
128033 BRD-K99383816 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
135533 BRD-K99383816 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135677 BRD-K99383816 JURKAT 0.03 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
135749 BRD-K99383816 YAPC 0.01 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).