CMap Candidate Details

Structure:
CMap ID: C03386
Pert ID: BRD-K03063480
Compound Name: PF-477736
Targets: CHEK1
MoA: CHK inhibitor
SMILES: Cn1cc(cn1)-c1[nH]c2cc(NC(=O)[C@H](N)C3CCCCC3)cc3c2c1cn[nH]c3=O
InchiKey: NDEXUOWTGYUVGA-LJQANCHMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91858 BRD-K03063480 MCF??7.00 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
91928 BRD-K03063480 SKBR3 10 uM 24 h 0.24 1.0 0.11 -0.33 -1.1 0.86
91996 BRD-K03063480 A375 1.11 uM 24 h 0.21 0.86 0.01 -0.37 -1.25 1.35
92024 BRD-K03063480 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92073 BRD-K03063480 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92106 BRD-K03063480 HCC515 10 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
92162 BRD-K03063480 HS578T 1.11 uM 3 h 0.24 0.98 0.09 0.24 0.85 0.14
92193 BRD-K03063480 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
92237 BRD-K03063480 MCF10A 10 uM 3 h 0.0 0.0 0.0 -0.36 -1.22 1.25
92315 BRD-K03063480 MDAMB231 1.11 uM 3 h 0.0 0.0 0.0 -0.3 -1.01 0.58
92343 BRD-K03063480 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).