CMap Candidate Details

Structure:
CMap ID: C33891
Pert ID: BRD-K99475619
Compound Name: genz-644282
Targets: TOP1
MoA: Topoisomerase inhibitor
SMILES: CNCCn1c2c(cnc3cc4OCOc4cc23)c2cc(OC)c(OC)cc2c1=O
InchiKey: BAORCAMWLWRZQG-UHFFFAOYSA-N
Compound Aliases: GENZ-644282

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127345 BRD-K99475619 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127419 BRD-K99475619 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127460 BRD-K99475619 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
127507 BRD-K99475619 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127600 BRD-K99475619 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127677 BRD-K99475619 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135345 BRD-K99475619 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135395 BRD-K99475619 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135433 BRD-K99475619 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135467 BRD-K99475619 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
135494 BRD-K99475619 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).