CMap Candidate Details

Structure:
CMap ID: C33920
Pert ID: BRD-K99545815
Compound Name: PF-562271
Targets: PTK2B
MoA: Focal adhesion kinase inhibitor
SMILES: CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
InchiKey: MZDKLVOWGIOKTN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33591 BRD-K99545815 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34225 BRD-K99545815 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34727 BRD-K99545815 HCC515 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.34
35005 BRD-K99545815 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36396 BRD-K99545815 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36696 BRD-K99545815 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91565 BRD-K99545815 BT20 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.28
91703 BRD-K99545815 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92495 BRD-K99545815 HA1E 1.11 uM 24 h -0.29 -1.23 0.62 0.0 0.0 0.0
92529 BRD-K99545815 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
92578 BRD-K99545815 HS578T 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92693 BRD-K99545815 LNCAP 1.11 uM 3 h 0.0 0.0 0.0 -0.42 -1.43 15.35
92713 BRD-K99545815 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92802 BRD-K99545815 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
92825 BRD-K99545815 SKBR3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128174 BRD-K99545815 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128270 BRD-K99545815 MCF??7.00 3.33 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
135783 BRD-K99545815 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135913 BRD-K99545815 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135953 BRD-K99545815 HT29 2.22 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
136003 BRD-K99545815 JURKAT 2.22 uM 24 h -0.22 -0.91 0.06 0.0 0.0 0.0
136098 BRD-K99545815 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136149 BRD-K99545815 YAPC 2.22 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).