CMap Candidate Details

Structure:
CMap ID: C33940
Pert ID: BRD-K99621550
Compound Name: tubocurarine
Targets: CHRNA2; HTR3A
MoA: Acetylcholine receptor antagonist
SMILES: COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
InchiKey: JFJZZMVDLULRGK-URLMMPGGSA-O
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5243 BRD-K99621550 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5382 BRD-K99621550 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5706 BRD-K99621550 HCC515 10 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
5967 BRD-K99621550 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6117 BRD-K99621550 MCF??7.00 10 uM 6 h -0.3 -1.26 0.72 0.0 0.0 0.0
6228 BRD-K99621550 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6609 BRD-K99621550 VCAP 10 uM 6 h 0.0 0.0 0.0 0.21 0.75 0.04
39387 BRD-K99621550 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39873 BRD-K99621550 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40416 BRD-K99621550 HT29 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.34 1.85
40967 BRD-K99621550 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41291 BRD-K99621550 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41636 BRD-K99621550 SKB 10 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
90940 BRD-K99621550 HUH7 6.66 uM 72 h 0.0 0.0 0.0 -0.24 -0.81 0.13
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).