CMap Candidate Details

Structure:
CMap ID: C33966
Pert ID: BRD-K99696746
Compound Name: fatostatin
Targets: SREBF1; SREBF2
MoA: SREBP inhibitor
SMILES: CCCc1cc(ccn1)c2nc(cs2)c3ccc(C)cc3
InchiKey: ZROSUBKIGBSZCG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9013 BRD-K99696746 A375 10 uM 24 h 0.21 0.89 0.02 0.28 0.98 0.36
9257 BRD-K99696746 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9865 BRD-K99696746 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10100 BRD-K99696746 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.06
10332 BRD-K99696746 HCC515 10 uM 6 h -0.22 -0.91 0.05 0.32 1.14 0.87
10888 BRD-K99696746 HEPG2 10 uM 6 h -0.21 -0.87 0.02 -0.29 -0.99 0.5
11046 BRD-K99696746 HT29 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
11211 BRD-K99696746 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11628 BRD-K99696746 NCIH2073 10 uM 6 h 0.22 0.93 0.05 -0.35 -1.17 1.13
12420 BRD-K99696746 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12534 BRD-K99696746 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
13714 BRD-K99696746 VCAP 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).