CMap Candidate Details

Structure:
CMap ID: C03399
Pert ID: BRD-K03095347
Compound Name: levosimendan
Targets: TNNC1
MoA: Calcium sensitizer
SMILES: C[C@@H]1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1
InchiKey: WHXMKTBCFHIYNQ-SECBINFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122841 BRD-K03095347 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122916 BRD-K03095347 HEK293 10 uM 24 h 0.31 1.29 0.66 -0.2 -0.66 0.01
122990 BRD-K03095347 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123041 BRD-K03095347 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123082 BRD-K03095347 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123131 BRD-K03095347 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123203 BRD-K03095347 THP1 10 uM 24 h 0.22 0.91 0.04 -0.37 -1.26 1.36
131259 BRD-K03095347 A549 0.01 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
131291 BRD-K03095347 HA1E 0.08 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
131315 BRD-K03095347 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131378 BRD-K03095347 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
131414 BRD-K03095347 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131472 BRD-K03095347 PC3 0.03 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
131511 BRD-K03095347 YAPC 0.01 uM 24 h 0.28 1.16 0.35 -0.33 -1.12 0.93
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).