CMap Candidate Details

Structure:
CMap ID: C34041
Pert ID: BRD-K99964838
Compound Name: bosutinib
Targets: ABL1; HCK; LYN; BCR; SRC; CAMK2G
MoA: Src inhibitor; Abl kinase inhibitor
SMILES: COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
InchiKey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33951 BRD-K99964838 A549 10 uM 6 h 0.0 0.0 0.0 0.43 1.51 2.28
34458 BRD-K99964838 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34730 BRD-K99964838 HCC515 10 uM 6 h 0.23 0.95 0.07 0.38 1.34 1.72
36398 BRD-K99964838 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
36698 BRD-K99964838 SKB 10 uM 24 h -0.24 -0.99 0.13 0.31 1.09 0.67
36908 BRD-K99964838 VCAP 10 uM 24 h -0.3 -1.26 0.71 0.29 1.03 0.5
87284 BRD-K99964838 BJAB 2.5 uM 24 h 0.21 0.87 0.01 0.28 1.01 0.44
87360 BRD-K99964838 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87410 BRD-K99964838 K562 0.66 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.08
87458 BRD-K99964838 KMS34 2.5 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
87504 BRD-K99964838 MINO 0.66 uM 3 h -0.23 -0.95 0.09 -0.36 -1.21 1.24
87562 BRD-K99964838 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87612 BRD-K99964838 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87663 BRD-K99964838 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87714 BRD-K99964838 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87761 BRD-K99964838 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87788 BRD-K99964838 THP1 2.5 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
87849 BRD-K99964838 TMD8 2.5 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
90870 BRD-K99964838 MCF10A 3.33 uM 3 h 0.0 0.0 0.0 0.28 0.99 0.39
92954 BRD-K99964838 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92982 BRD-K99964838 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93072 BRD-K99964838 HEK293 10 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
93159 BRD-K99964838 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93208 BRD-K99964838 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
93265 BRD-K99964838 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93348 BRD-K99964838 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93473 BRD-K99964838 SKL 1.11 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
93575 BRD-K99964838 YAPC 1.11 uM 24 h -0.26 -1.09 0.32 0.0 0.0 0.0
95372 BRD-K99964838 MCF??7.00 10 uM 6 h 0.21 0.88 0.01 0.0 0.0 0.0
95419 BRD-K99964838 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
97271 BRD-K99964838 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98783 BRD-K99964838 NPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
99113 BRD-K99964838 NEU 10 uM 6 h 0.2 0.85 0.01 0.0 0.0 0.0
120255 BRD-K99964838 A375 0.37 uM 24 h -0.28 -1.15 0.44 -0.29 -0.99 0.5
120355 BRD-K99964838 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120448 BRD-K99964838 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128961 BRD-K99964838 HT29 2.22 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).