CMap Candidate Details

Structure:
CMap ID: C34062
Pert ID: BRD-M07438658
Compound Name: lapatinib
Targets: EGFR; ERBB2
MoA: EGFR inhibitor; ErbB2 inhibitor
SMILES: CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
InchiKey: BCFGMOOMADDAQU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25619 BRD-M07438658 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26184 BRD-M07438658 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26530 BRD-M07438658 ASC 10 uM 24 h -0.23 -0.97 0.1 0.0 0.0 0.0
26845 BRD-M07438658 HA1E 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
27148 BRD-M07438658 HCC515 10 uM 6 h 0.0 0.0 0.0 0.44 1.55 2.32
27461 BRD-M07438658 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27645 BRD-M07438658 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28409 BRD-M07438658 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
28556 BRD-M07438658 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29037 BRD-M07438658 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29379 BRD-M07438658 SKB 10 uM 24 h 0.0 0.0 0.0 0.46 1.61 2.39
29579 BRD-M07438658 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).