CMap Candidate Details

Structure:
CMap ID: C34173
Pert ID: BRD-M64432851
Compound Name: sunitinib
Targets: FLT1; FLT3; FLT4; KDR; KIT; PDGFRA; PDGFRB; RET
MoA: KIT inhibitor; FLT3 inhibitor; PDGFR inhibitor; VEGFR inhibitor; RET tyrosine kinase inhibitor
SMILES: CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2/C(=O)Nc3ccc(F)cc23)c1C
InchiKey: WINHZLLDWRZWRT-ATVHPVEESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33557 BRD-M64432851 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33953 BRD-M64432851 A549 10 uM 6 h 0.0 0.0 0.0 0.26 0.94 0.28
34229 BRD-M64432851 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34461 BRD-M64432851 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34733 BRD-M64432851 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35008 BRD-M64432851 HEPG2 10 uM 6 h 0.17 0.7 0.0 0.0 0.0 0.0
35241 BRD-M64432851 HT29 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.7
35364 BRD-M64432851 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35651 BRD-M64432851 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35883 BRD-M64432851 NPC 10 uM 24 h -0.23 -0.94 0.08 -0.26 -0.87 0.23
36020 BRD-M64432851 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36400 BRD-M64432851 PHH 10 uM 24 h 0.19 0.77 0.0 0.0 0.0 0.0
36701 BRD-M64432851 SKB 10 uM 24 h -0.31 -1.29 0.77 -0.24 -0.82 0.15
36911 BRD-M64432851 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).