CMap Candidate Details

Structure:
CMap ID: C34203
Pert ID: BRD-M80207679
Compound Name: nemonapride
Targets: DRD2; DRD3
MoA: Dopamine receptor antagonist
SMILES: CNc1cc(OC)c(cc1Cl)C(=O)N[C@@H]1CCN(Cc2ccccc2)[C@@H]1C.CNc1cc(OC)c(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccccc2)[C@H]1C
InchiKey: QCYCDKUNJFKYEI-ZVWWNKPMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125958 BRD-M80207679 A375 1.11 uM 24 h 0.26 1.09 0.23 0.31 1.1 0.71
125975 BRD-M80207679 A549 3.33 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
126066 BRD-M80207679 HUVEC 3.33 uM 24 h -0.24 -1.01 0.16 -0.22 -0.73 0.05
126106 BRD-M80207679 JURKAT 1.11 uM 24 h -0.35 -1.46 1.43 0.0 0.0 0.0
126161 BRD-M80207679 MCF10A 1.11 uM 24 h 0.31 1.27 0.58 0.0 0.0 0.0
126212 BRD-M80207679 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126228 BRD-M80207679 MDAMB231 10 uM 24 h -0.15 -0.64 0.0 0.23 0.83 0.11
126279 BRD-M80207679 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
134058 BRD-M80207679 HA1E 0.08 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
134080 BRD-M80207679 HEK293 0.25 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
134135 BRD-M80207679 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134171 BRD-M80207679 HT29 2.22 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
134280 BRD-M80207679 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.85
134301 BRD-M80207679 YAPC 0.01 uM 24 h -0.24 -0.99 0.13 -0.37 -1.25 1.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).