CMap Candidate Details

Structure:
CMap ID: C03422
Pert ID: BRD-K03194791
Compound Name: roflumilast
Targets: PDE4A; PDE4B; PDE4C; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
InchiKey: MNDBXUUTURYVHR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1422 BRD-K03194791 NPC 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96714 BRD-K03194791 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122866 BRD-K03194791 HA1E 0.04 uM 24 h 0.2 0.84 0.0 -0.27 -0.92 0.33
122913 BRD-K03194791 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122987 BRD-K03194791 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123038 BRD-K03194791 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123128 BRD-K03194791 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123154 BRD-K03194791 PC3 0.04 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
123200 BRD-K03194791 THP1 0.04 uM 24 h 0.23 0.96 0.08 0.2 0.7 0.02
123221 BRD-K03194791 YAPC 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
131256 BRD-K03194791 A549 0.03 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
131314 BRD-K03194791 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
131375 BRD-K03194791 HUVEC 0.03 uM 24 h 0.26 1.07 0.2 0.28 0.99 0.39
131412 BRD-K03194791 MCF10A 2.22 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
131447 BRD-K03194791 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).