CMap Candidate Details

Structure:
CMap ID: C34312
Pert ID: BRD-U70626184
Compound Name: BI-2536
Targets: PLK1
MoA: PLK inhibitor
SMILES: CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
InchiKey: XQVVPGYIWAGRNI-JOCHJYFZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94403 BRD-U70626184 A375 10 uM 24 h -0.24 -1.02 0.17 0.31 1.11 0.72
94435 BRD-U70626184 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94505 BRD-U70626184 ASC 0.37 uM 24 h 0.27 1.12 0.26 -0.29 -0.97 0.45
94529 BRD-U70626184 CD34 10 uM 24 h -0.36 -1.5 1.43 0.0 0.0 0.0
94583 BRD-U70626184 HCC515 10 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
94623 BRD-U70626184 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94673 BRD-U70626184 HELA 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94722 BRD-U70626184 HME1 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
94778 BRD-U70626184 HT29 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
94818 BRD-U70626184 HUVEC 0.04 uM 24 h 0.19 0.81 0.0 0.19 0.67 0.01
94870 BRD-U70626184 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94922 BRD-U70626184 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94965 BRD-U70626184 MCF??7.00 10 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
94997 BRD-U70626184 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95045 BRD-U70626184 NPC 10 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
95104 BRD-U70626184 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95142 BRD-U70626184 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
95194 BRD-U70626184 SKL 10 uM 24 h -0.29 -1.21 0.59 0.34 1.19 1.03
95255 BRD-U70626184 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).