CMap Candidate Details

Structure:
CMap ID: C34324
Pert ID: BRD-U86686840
Compound Name: AZD-7762
Targets: CHEK1; CHEK2
MoA: CHK inhibitor
SMILES: C1C[C@H](CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N
InchiKey: IAYGCINLNONXHY-GFCCVEGCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94401 BRD-U86686840 A375 10 uM 24 h -0.28 -1.17 0.48 0.0 0.0 0.0
94433 BRD-U86686840 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94504 BRD-U86686840 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
94527 BRD-U86686840 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94581 BRD-U86686840 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94621 BRD-U86686840 HEK293 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
94671 BRD-U86686840 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94720 BRD-U86686840 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94776 BRD-U86686840 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94816 BRD-U86686840 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94868 BRD-U86686840 JURKAT 10 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
94920 BRD-U86686840 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94963 BRD-U86686840 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
94995 BRD-U86686840 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95086 BRD-U86686840 NPC 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
95102 BRD-U86686840 PC3 10 uM 24 h 0.0 0.0 0.0 0.2 0.69 0.01
95140 BRD-U86686840 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95226 BRD-U86686840 SKL 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
95253 BRD-U86686840 THP1 10 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).