CMap Candidate Details

Structure:
CMap ID: C34327
Pert ID: BRD-U88459701
Compound Name: atorvastatin
Targets: DPP4; HMGCR
MoA: HMGCR inhibitor
SMILES: CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CCC(O)CC(O)CC(O)=O)-c1ccccc1
InchiKey: XUKUURHRXDUEBC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9015 BRD-U88459701 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9133 BRD-U88459701 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
9560 BRD-U88459701 AGS 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.69
9867 BRD-U88459701 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9930 BRD-U88459701 HA1E 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
10183 BRD-U88459701 HCC515 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.09
11048 BRD-U88459701 HT29 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
11185 BRD-U88459701 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
11631 BRD-U88459701 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.3 1.06 0.58
12184 BRD-U88459701 NCIH596 10 uM 6 h -0.18 -0.77 0.0 0.0 0.0 0.0
12422 BRD-U88459701 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.27
12501 BRD-U88459701 PC3 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
12917 BRD-U88459701 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13022 BRD-U88459701 THP1 10 uM 6 h 0.0 0.0 0.0 0.39 1.37 2.09
13409 BRD-U88459701 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13521 BRD-U88459701 VCAP 10 uM 24 h 0.0 0.0 0.0 0.35 1.22 1.15
53488 BRD-U88459701 HEPG2 2.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
53541 BRD-U88459701 HUH7 10 uM 24 h 0.35 1.47 1.12 0.0 0.0 0.0
53704 BRD-U88459701 PHH 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).