CMap Candidate Details

Structure:
CMap ID: C03437
Pert ID: BRD-K03243820
Compound Name: trifluridine
Targets: TYMS
MoA: Thymidylate synthase inhibitor; DNA directed DNA polymerase inhibitor
SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
InchiKey: VSQQQLOSPVPRAZ-RRKCRQDMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
52260 BRD-K03243820 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95489 BRD-K03243820 A549 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
95605 BRD-K03243820 MCF??7.00 10 uM 6 h 0.28 1.16 0.36 0.0 0.0 0.0
95710 BRD-K03243820 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98557 BRD-K03243820 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98626 BRD-K03243820 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).