CMap Candidate Details

Structure:
CMap ID: C03465
Pert ID: BRD-K03319035
Compound Name: maprotiline
Targets: SLC6A2
MoA: Tricyclic antidepressant; Norepinephrine reputake inhibitor
SMILES: CNCCC[C@]1(CC[C@H]2c3ccccc31)c4ccccc24
InchiKey: QSLMDECMDJKHMQ-GSXCWMCISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6972 BRD-K03319035 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
7289 BRD-K03319035 HA1E 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
7616 BRD-K03319035 HCC515 10 uM 6 h -0.24 -0.99 0.14 0.31 1.09 0.67
7984 BRD-K03319035 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8642 BRD-K03319035 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51208 BRD-K03319035 MCF??7.00 10 uM 24 h -0.27 -1.11 0.36 -0.34 -1.16 1.11
90600 BRD-K03319035 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90674 BRD-K03319035 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91091 BRD-K03319035 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96302 BRD-K03319035 A375 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
96374 BRD-K03319035 PC3 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).