CMap Candidate Details

Structure:
CMap ID: C03496
Pert ID: BRD-K03390685
Compound Name: cobimetinib
Targets: --
MoA: --
SMILES: OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1
InchiKey: BSMCAPRUBJMWDF-KRWDZBQOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
67 BRD-K03390685 BJAB 10 uM 4 h 0.33 1.39 1.02 0.0 0.0 0.0
100 BRD-K03390685 HBL1 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
156 BRD-K03390685 K562 10 uM 4 h 0.0 0.0 0.0 0.24 0.86 0.15
191 BRD-K03390685 KMS34 0.125 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
230 BRD-K03390685 NALM6 0.125 uM 24 h 0.25 1.04 0.15 -0.23 -0.77 0.08
270 BRD-K03390685 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
294 BRD-K03390685 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
352 BRD-K03390685 OCILY3 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
388 BRD-K03390685 SKMEL5 0.01 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
409 BRD-K03390685 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
469 BRD-K03390685 TMD8 2.5 uM 4 h -0.22 -0.93 0.07 0.0 0.0 0.0
95379 BRD-K03390685 MCF??7.00 10 uM 6 h 0.28 1.18 0.39 0.33 1.16 0.9
95412 BRD-K03390685 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122843 BRD-K03390685 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122920 BRD-K03390685 HEK293 10 uM 24 h 0.3 1.24 0.51 0.25 0.89 0.2
122953 BRD-K03390685 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
122993 BRD-K03390685 HT29 3.33 uM 24 h 0.16 0.66 0.0 -0.25 -0.84 0.18
123045 BRD-K03390685 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123135 BRD-K03390685 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131261 BRD-K03390685 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131293 BRD-K03390685 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
131382 BRD-K03390685 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131417 BRD-K03390685 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131474 BRD-K03390685 PC3 0.74 uM 24 h 0.27 1.13 0.29 0.24 0.84 0.12
131515 BRD-K03390685 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).