CMap Candidate Details

Structure:
CMap ID: C03733
Pert ID: BRD-K04218075
Compound Name: clomifene
Targets: ESR1
MoA: Estrogen receptor antagonist
SMILES: CCN(CC)CCOc1ccc(cc1)/C(=C(/Cl)c2ccccc2)/c3ccccc3
InchiKey: GKIRPKYJQBWNGO-OCEACIFDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4044 BRD-K04218075 HA1E 10 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.59
4881 BRD-K04218075 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37582 BRD-K04218075 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38418 BRD-K04218075 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38682 BRD-K04218075 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90642 BRD-K04218075 HCT116 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
90660 BRD-K04218075 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
91475 BRD-K04218075 HUH7 8 uM 72 h 0.0 0.0 0.0 0.39 1.38 2.16
119386 BRD-K04218075 A375 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.1
119420 BRD-K04218075 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119484 BRD-K04218075 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119521 BRD-K04218075 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
119555 BRD-K04218075 HT29 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
119587 BRD-K04218075 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
119618 BRD-K04218075 PC3 10 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).