CMap Candidate Details

Structure:
CMap ID: C00379
Pert ID: BRD-A14941520
Compound Name: dofequidar
Targets: ABCC1; ABCB1
MoA: MRP inhibitor; P-glycoprotein inhibitor
SMILES: OC(COc1cccc2ncccc12)CN1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1
InchiKey: KLWUUPVJTLHYIM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96494 BRD-A14941520 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122374 BRD-A14941520 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122400 BRD-A14941520 MCF??7.00 1.11 uM 24 h 0.27 1.13 0.29 -0.38 -1.27 1.43
122426 BRD-A14941520 MDAMB231 0.37 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
122493 BRD-A14941520 THP1 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
130570 BRD-A14941520 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130602 BRD-A14941520 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130637 BRD-A14941520 HEK293 2.22 uM 24 h -0.2 -0.83 0.0 -0.29 -0.99 0.51
130680 BRD-A14941520 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130722 BRD-A14941520 HT29 2.22 uM 24 h 0.18 0.73 0.0 -0.19 -0.65 0.01
130820 BRD-A14941520 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130846 BRD-A14941520 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).