CMap Candidate Details

Structure:
CMap ID: C03796
Pert ID: BRD-K04412738
Compound Name: tramadol
Targets: OPRM1; SLC6A2; SLC6A4
MoA: Opioid receptor agonist; Serotonin reuptake inhibitor; Norepinephrine reputake inhibitor
SMILES: COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C
InchiKey: TVYLLZQTGLZFBW-ZBFHGGJFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
21841 BRD-K04412738 A375 10 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
22232 BRD-K04412738 A549 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.27 1.43
22421 BRD-K04412738 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22685 BRD-K04412738 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22968 BRD-K04412738 HEPG2 10 uM 6 h 0.2 0.84 0.0 0.0 0.0 0.0
23275 BRD-K04412738 HT29 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.66
23537 BRD-K04412738 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
23958 BRD-K04412738 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24110 BRD-K04412738 VCAP 10 uM 24 h -0.22 -0.9 0.04 -0.25 -0.85 0.19
91254 BRD-K04412738 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).