CMap Candidate Details

Structure:
CMap ID: C03836
Pert ID: BRD-K04548931
Compound Name: epirubicin
Targets: TOP2A
MoA: Topoisomerase inhibitor
SMILES: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InchiKey: AOJJSUZBOXZQNB-VTZDEGQISA-N
Compound Aliases: pidorubicine

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1319 BRD-K04548931 U2OS 0.12 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
5177 BRD-K04548931 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5424 BRD-K04548931 HA1E 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.49
5753 BRD-K04548931 HCC515 10 uM 6 h 0.0 0.0 0.0 0.34 1.21 1.15
5877 BRD-K04548931 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
6001 BRD-K04548931 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6256 BRD-K04548931 PC3 10 uM 6 h 0.0 0.0 0.0 0.36 1.26 1.29
6514 BRD-K04548931 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37363 BRD-K04548931 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37583 BRD-K04548931 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38178 BRD-K04548931 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38906 BRD-K04548931 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).