CMap Candidate Details

Structure:
CMap ID: C00393
Pert ID: BRD-A15297126
Compound Name: fluocinolone-acetonide
Targets: NR3C1
MoA: Corticosteroid agonist; Glucocorticoid receptor agonist
SMILES: CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1CC1C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C
InchiKey: WJOHZNCJWYWUJD-UUTDCOIBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7510 BRD-A15297126 HCC515 10 uM 6 h -0.24 -1.0 0.15 -0.28 -0.93 0.35
8552 BRD-A15297126 VCAP 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
122275 BRD-A15297126 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122339 BRD-A15297126 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122348 BRD-A15297126 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122377 BRD-A15297126 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122451 BRD-A15297126 PC3 1.11 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
122500 BRD-A15297126 THP1 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
130573 BRD-A15297126 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130605 BRD-A15297126 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130644 BRD-A15297126 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130769 BRD-A15297126 MCF??7.00 2.22 uM 24 h -0.19 -0.81 0.0 0.0 0.0 0.0
130800 BRD-A15297126 MDAMB231 0.25 uM 24 h -0.22 -0.9 0.04 -0.34 -1.13 0.98
130850 BRD-A15297126 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).