CMap Candidate Details

Structure:
CMap ID: C03959
Pert ID: BRD-K04956647
Compound Name: nebivolol
Targets: ADRB1
MoA: Adrenergic receptor antagonist
SMILES: O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O1
InchiKey: KOHIRBRYDXPAMZ-YHBROIRLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122535 BRD-K04956647 A375 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.56
122566 BRD-K04956647 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122594 BRD-K04956647 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122652 BRD-K04956647 HELA 10 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
122671 BRD-K04956647 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122701 BRD-K04956647 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122744 BRD-K04956647 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122784 BRD-K04956647 PC3 10 uM 24 h -0.25 -1.06 0.25 -0.22 -0.73 0.05
130926 BRD-K04956647 HEK293 0.74 uM 24 h 0.27 1.12 0.27 -0.27 -0.9 0.29
131023 BRD-K04956647 HUVEC 0.74 uM 24 h -0.33 -1.38 1.09 0.0 0.0 0.0
131108 BRD-K04956647 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131172 BRD-K04956647 YAPC 0.03 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).