CMap Candidate Details

Structure:
CMap ID: C04095
Pert ID: BRD-K05395900
Compound Name: nicotine
Targets: CHRNA4; CHRNB2; CHRNA9; CHRNA10
MoA: Acetylcholine receptor agonist
SMILES: CN1CCC[C@H]1c1cccnc1
InchiKey: SNICXCGAKADSCV-JTQLQIEISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7291 BRD-K05395900 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7618 BRD-K05395900 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7830 BRD-K05395900 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51002 BRD-K05395900 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122570 BRD-K05395900 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122626 BRD-K05395900 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122708 BRD-K05395900 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122809 BRD-K05395900 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130863 BRD-K05395900 A375 0.03 uM 24 h 0.3 1.26 0.58 0.0 0.0 0.0
130958 BRD-K05395900 HELA 0.03 uM 24 h 0.19 0.8 0.0 -0.27 -0.91 0.3
131030 BRD-K05395900 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131079 BRD-K05395900 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131112 BRD-K05395900 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.28
131143 BRD-K05395900 PC3 0.01 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).