CMap Candidate Details

Structure:
CMap ID: C04253
Pert ID: BRD-K05870596
Compound Name: XMD-1499
Targets: EPHB3
MoA: EPHB3 inhibitor
SMILES: COc1cc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCN(C)CC1
InchiKey: UISRWLSAXIOCND-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91794 BRD-K05870596 HS578T 0.08 uM 6 h 0.25 1.03 0.14 0.0 0.0 0.0
91910 BRD-K05870596 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.38
91956 BRD-K05870596 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
94399 BRD-K05870596 A375 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.55
94431 BRD-K05870596 A549 10 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
94501 BRD-K05870596 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
94523 BRD-K05870596 CD34 10 uM 24 h 0.35 1.46 1.12 -0.26 -0.88 0.25
94579 BRD-K05870596 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94618 BRD-K05870596 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94668 BRD-K05870596 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
94716 BRD-K05870596 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94774 BRD-K05870596 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94811 BRD-K05870596 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
94865 BRD-K05870596 JURKAT 10 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
94917 BRD-K05870596 MCF10A 0.37 uM 24 h 0.2 0.84 0.0 -0.23 -0.76 0.08
94960 BRD-K05870596 MCF??7.00 10 uM 24 h -0.32 -1.35 0.98 0.0 0.0 0.0
94992 BRD-K05870596 NEU 0.12 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
95043 BRD-K05870596 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95099 BRD-K05870596 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95136 BRD-K05870596 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95191 BRD-K05870596 SKL 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
95250 BRD-K05870596 THP1 10 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).