CMap Candidate Details

Structure:
CMap ID: C04364
Pert ID: BRD-K06217810
Compound Name: BRD-K06217810
Targets: CLK1; DYRK1A; CLK4; DYRK1B
MoA: DYRK inhibitor
SMILES: CN(Cc1csc(C)n1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1
InchiKey: PMDAVRLCSZSLRH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22015 BRD-K06217810 A375 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.63
22108 BRD-K06217810 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
22425 BRD-K06217810 HA1E 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.13
22689 BRD-K06217810 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22972 BRD-K06217810 HEPG2 10 uM 6 h 0.27 1.13 0.29 0.0 0.0 0.0
23279 BRD-K06217810 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23695 BRD-K06217810 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23960 BRD-K06217810 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24278 BRD-K06217810 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115009 BRD-K06217810 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).