CMap Candidate Details

Structure:
CMap ID: C04372
Pert ID: BRD-K06234293
Compound Name: LY-364947
Targets: TGFBR1
MoA: P38 MAPK inhibitor; TGF beta receptor inhibitor
SMILES: c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1
InchiKey: IBCXZJCWDGCXQT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4046 BRD-K06234293 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4348 BRD-K06234293 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5025 BRD-K06234293 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44662 BRD-K06234293 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44832 BRD-K06234293 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45143 BRD-K06234293 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.27 1.44
45411 BRD-K06234293 HT29 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.31
45642 BRD-K06234293 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45947 BRD-K06234293 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46266 BRD-K06234293 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46582 BRD-K06234293 SKB 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
96474 BRD-K06234293 A375 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
96540 BRD-K06234293 PC3 3.33 uM 24 h 0.32 1.32 0.79 0.2 0.72 0.02
97322 BRD-K06234293 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.93
100009 BRD-K06234293 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).