CMap Candidate Details

Structure:
CMap ID: C04418
Pert ID: BRD-K06388322
Compound Name: pramipexole
Targets: DRD2; DRD3
MoA: Dopamine receptor agonist
SMILES: CCCN[C@H]1CCc2nc(N)sc2C1
InchiKey: FASDKYOPVNHBLU-ZETCQYMHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1441 BRD-K06388322 NPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24551 BRD-K06388322 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24869 BRD-K06388322 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25487 BRD-K06388322 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91242 BRD-K06388322 HUH7 15 uM 72 h -0.23 -0.96 0.1 0.31 1.11 0.72
122544 BRD-K06388322 A375 0.04 uM 24 h -0.23 -0.96 0.1 -0.27 -0.91 0.3
122632 BRD-K06388322 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
122717 BRD-K06388322 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130912 BRD-K06388322 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130963 BRD-K06388322 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131039 BRD-K06388322 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131081 BRD-K06388322 MCF??7.00 0.25 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
131116 BRD-K06388322 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131149 BRD-K06388322 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131182 BRD-K06388322 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).