CMap Candidate Details

Structure:
CMap ID: C04436
Pert ID: BRD-K06426971
Compound Name: ryuvidine
Targets: CDK4
MoA: Histone lysine methyltransferase inhibitor
SMILES: Cc1nc2c(s1)C(=O)C=C(Nc1ccc(C)cc1)C2=O
InchiKey: HFPLHASLIOXVGS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1731 BRD-K06426971 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2073 BRD-K06426971 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2366 BRD-K06426971 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2714 BRD-K06426971 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.52
41712 BRD-K06426971 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42048 BRD-K06426971 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42274 BRD-K06426971 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42610 BRD-K06426971 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42914 BRD-K06426971 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43286 BRD-K06426971 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43469 BRD-K06426971 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44055 BRD-K06426971 SKB 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
53497 BRD-K06426971 HUH7 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53640 BRD-K06426971 PHH 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
100010 BRD-K06426971 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).