CMap Candidate Details

Structure:
CMap ID: C04477
Pert ID: BRD-K06543683
Compound Name: bisindolylmaleimide-ix
Targets: SIRT1
MoA: PKC inhibitor
SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12
InchiKey: DSXXEELGXBCYNQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5425 BRD-K06543683 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5571 BRD-K06543683 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6258 BRD-K06543683 PC3 10 uM 6 h 0.0 0.0 0.0 0.26 0.92 0.25
39296 BRD-K06543683 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39623 BRD-K06543683 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39944 BRD-K06543683 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.15
40224 BRD-K06543683 HT29 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.62
40587 BRD-K06543683 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40747 BRD-K06543683 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41375 BRD-K06543683 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97335 BRD-K06543683 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97343 BRD-K06543683 A375 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100013 BRD-K06543683 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).