CMap Candidate Details

Structure:
CMap ID: C04482
Pert ID: BRD-K06557128
Compound Name: voriconazole
Targets: CYP2C19; CYP2C9; CYP3A4; CYP3A5; PTGS1
MoA: Cytochrome P450 inhibitor
SMILES: C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InchiKey: BCEHBSKCWLPMDN-MGPLVRAMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24651 BRD-K06557128 A549 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.08
25488 BRD-K06557128 VCAP 10 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.34
122634 BRD-K06557128 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122721 BRD-K06557128 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122754 BRD-K06557128 MCF??7.00 0.125 uM 24 h 0.25 1.04 0.14 -0.21 -0.7 0.03
122773 BRD-K06557128 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
122793 BRD-K06557128 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
122815 BRD-K06557128 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
130867 BRD-K06557128 A375 0.01 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
130914 BRD-K06557128 HA1E 0.74 uM 24 h -0.21 -0.88 0.03 -0.32 -1.06 0.74
130967 BRD-K06557128 HELA 0.25 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
131000 BRD-K06557128 HT29 0.08 uM 24 h 0.28 1.15 0.32 -0.23 -0.79 0.1
131043 BRD-K06557128 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).