CMap Candidate Details

Structure:
CMap ID: C04548
Pert ID: BRD-K06792661
Compound Name: narciclasine
Targets: RHOA
MoA: LIM kinase activator; Rho associated kinase activator; Coflilin signaling pathway activator
SMILES: O[C@H]1C=C2[C@@H](NC(=O)c3c(O)c4OCOc4cc23)[C@H](O)[C@@H]1O
InchiKey: LZAZURSABQIKGB-AEKGRLRDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9017 BRD-K06792661 A375 10 uM 6 h 0.3 1.27 0.58 -0.43 -1.45 15.35
9348 BRD-K06792661 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9654 BRD-K06792661 H1299 10 uM 6 h 0.34 1.43 1.12 -0.45 -1.52 15.35
10027 BRD-K06792661 HA1E 10 uM 6 h 0.24 1.01 0.12 0.0 0.0 0.0
10108 BRD-K06792661 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10451 BRD-K06792661 HCT116 10 uM 6 h 0.32 1.35 0.94 -0.48 -1.61 15.65
10719 BRD-K06792661 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11050 BRD-K06792661 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11405 BRD-K06792661 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.62 15.65
11703 BRD-K06792661 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11975 BRD-K06792661 NCIH596 10 uM 6 h 0.26 1.07 0.2 -0.59 -1.98 15.65
12720 BRD-K06792661 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90565 BRD-K06792661 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
119723 BRD-K06792661 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119772 BRD-K06792661 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119808 BRD-K06792661 PC3 0.125 uM 24 h 0.0 0.0 0.0 -0.4 -1.33 1.81
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).