CMap Candidate Details

Structure:
CMap ID: C00461
Pert ID: BRD-A18328003
Compound Name: GDC-0980
Targets: MTOR; PIK3CG
MoA: MTOR inhibitor; PI3K inhibitor
SMILES: CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O
InchiKey: YOVVNQKCSKSHKT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91999 BRD-A18328003 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92043 BRD-A18328003 BT20 10 uM 3 h 0.0 0.0 0.0 0.37 1.3 1.49
92075 BRD-A18328003 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
92109 BRD-A18328003 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92164 BRD-A18328003 HS578T 10 uM 3 h 0.32 1.33 0.85 0.0 0.0 0.0
92195 BRD-A18328003 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92218 BRD-A18328003 MCF10A 0.37 uM 24 h -0.31 -1.3 0.82 0.0 0.0 0.0
92275 BRD-A18328003 MCF??7.00 3.33 uM 3 h 0.21 0.88 0.01 0.23 0.83 0.12
92295 BRD-A18328003 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
92346 BRD-A18328003 PC3 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
92392 BRD-A18328003 SKBR3 0.37 uM 3 h 0.0 0.0 0.0 -0.18 -0.59 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).