CMap Candidate Details

Structure:
CMap ID: C00463
Pert ID: BRD-A18419789
Compound Name: etoposide
Targets: TOP2A; TOP2B
MoA: Topoisomerase inhibitor
SMILES: COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(OCC3=O)C(OC4OC5COC(C)OC5C(O)C4O)c6cc7OCOc7cc26
InchiKey: SYKHAYBRYKMZLP-LTGYLHEKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6830 BRD-A18419789 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7058 BRD-A18419789 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7380 BRD-A18419789 HA1E 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
7513 BRD-A18419789 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7750 BRD-A18419789 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
8040 BRD-A18419789 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8296 BRD-A18419789 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8747 BRD-A18419789 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).