CMap Candidate Details

Structure:
CMap ID: C04644
Pert ID: BRD-K07106112
Compound Name: BMS-599626
Targets: EGFR; ERBB2; ERBB4
MoA: EGFR inhibitor; Receptor tyrosine protein kinase inhibitor
SMILES: Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c12
InchiKey: LUJZZYWHBDHDQX-QFIPXVFZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122549 BRD-K07106112 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122580 BRD-K07106112 A549 10 uM 24 h -0.25 -1.04 0.21 0.35 1.24 1.28
122636 BRD-K07106112 HEK293 10 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
122725 BRD-K07106112 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122756 BRD-K07106112 MCF??7.00 10 uM 24 h -0.18 -0.77 0.0 0.0 0.0 0.0
122774 BRD-K07106112 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130917 BRD-K07106112 HA1E 2.22 uM 24 h 0.25 1.05 0.17 -0.29 -0.96 0.43
130970 BRD-K07106112 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131002 BRD-K07106112 HT29 0.01 uM 24 h 0.24 1.02 0.13 -0.33 -1.12 0.95
131047 BRD-K07106112 HUVEC 2.22 uM 24 h 0.2 0.84 0.0 -0.29 -0.97 0.46
131152 BRD-K07106112 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131186 BRD-K07106112 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).