CMap Candidate Details

Structure:
CMap ID: C04696
Pert ID: BRD-K07310275
Compound Name: PF-04691502
Targets: MTOR; PIK3CA
MoA: MTOR inhibitor; PI3K inhibitor
SMILES: COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCCO)c1=O
InchiKey: XDLYKKIQACFMJG-WKILWMFISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
505 BRD-K07310275 BJAB 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
559 BRD-K07310275 HBL1 10 uM 4 h -0.25 -1.02 0.19 0.2 0.71 0.02
602 BRD-K07310275 K562 10 uM 4 h 0.0 0.0 0.0 -0.4 -1.35 1.86
641 BRD-K07310275 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
687 BRD-K07310275 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
734 BRD-K07310275 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
768 BRD-K07310275 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
837 BRD-K07310275 OCILY3 10 uM 4 h -0.21 -0.86 0.02 -0.23 -0.76 0.07
877 BRD-K07310275 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
917 BRD-K07310275 THP1 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
941 BRD-K07310275 TMD8 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
122584 BRD-K07310275 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
122607 BRD-K07310275 HA1E 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
122642 BRD-K07310275 HEK293 3.33 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
122688 BRD-K07310275 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.01
122735 BRD-K07310275 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.22 -0.76 0.07
122801 BRD-K07310275 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.13
122822 BRD-K07310275 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130872 BRD-K07310275 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130977 BRD-K07310275 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131057 BRD-K07310275 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131092 BRD-K07310275 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
131129 BRD-K07310275 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).