CMap Candidate Details

Structure:
CMap ID: C04732
Pert ID: BRD-K07403598
Compound Name: CAY-10470
Targets: NFKB1; TNF
MoA: NFKB pathway inhibitor
SMILES: Nc1ccc2NCN=C(NCCc3ccc(Oc4ccccc4)cc3)c2c1
InchiKey: GGBVTWRQPMDRCK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25643 BRD-K07403598 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25900 BRD-K07403598 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26250 BRD-K07403598 ASC 10 uM 24 h 0.19 0.81 0.0 -0.23 -0.78 0.09
26590 BRD-K07403598 HA1E 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.48
26902 BRD-K07403598 HCC515 10 uM 6 h 0.0 0.0 0.0 0.22 0.77 0.06
27210 BRD-K07403598 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27497 BRD-K07403598 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
27837 BRD-K07403598 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28146 BRD-K07403598 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
28441 BRD-K07403598 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28786 BRD-K07403598 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29101 BRD-K07403598 SKB 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.3
29600 BRD-K07403598 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).