CMap Candidate Details

Structure:
CMap ID: C00477
Pert ID: BRD-A18917088
Compound Name: estradiol
Targets: ESR1; ESR2; NR1I2
MoA: Estrogen receptor agonist
SMILES: C[C@]12CCC3C(CCc4cc(O)ccc34)C1CC[C@@H]2O
InchiKey: VOXZDWNPVJITMN-PAOLREHBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5256 BRD-A18917088 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5503 BRD-A18917088 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5828 BRD-A18917088 HEPG2 10 uM 6 h -0.27 -1.14 0.42 -0.26 -0.88 0.25
6452 BRD-A18917088 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44477 BRD-A18917088 A549 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
44750 BRD-A18917088 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45870 BRD-A18917088 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46182 BRD-A18917088 PHH 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
46499 BRD-A18917088 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96376 BRD-A18917088 PC3 10 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
121358 BRD-A18917088 A375 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
121397 BRD-A18917088 HELA 10 uM 24 h 0.22 0.92 0.04 -0.36 -1.21 1.24
121431 BRD-A18917088 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
121495 BRD-A18917088 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129509 BRD-A18917088 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).