CMap Candidate Details

Structure:
CMap ID: C04805
Pert ID: BRD-K07572174
Compound Name: curcumin
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor; Lipoxygenase inhibitor; NFKB pathway inhibitor; Histone acetyltransferase inhibitor
SMILES: COc1cc(ccc1O)C=CC(=O)CC(=O)C=Cc1ccc(O)c(OC)c1
InchiKey: VFLDPWHFBUODDF-FCXRPNKRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
53350 BRD-K07572174 MCF10A 100 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95443 BRD-K07572174 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
119020 BRD-K07572174 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119144 BRD-K07572174 PC3 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
119388 BRD-K07572174 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119486 BRD-K07572174 HCC515 100 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119523 BRD-K07572174 HEPG2 30 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119728 BRD-K07572174 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124309 BRD-K07572174 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124328 BRD-K07572174 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124367 BRD-K07572174 HELA 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
124393 BRD-K07572174 HT29 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
124471 BRD-K07572174 MCF??7.00 10 uM 24 h 0.21 0.87 0.01 0.3 1.06 0.6
124498 BRD-K07572174 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124560 BRD-K07572174 YAPC 10 uM 24 h 0.18 0.76 0.0 0.36 1.27 1.34
132625 BRD-K07572174 THP1 2.22 uM 24 h 0.19 0.81 0.0 -0.27 -0.93 0.34
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).