CMap Candidate Details

Structure:
CMap ID: C04839
Pert ID: BRD-K07667918
Compound Name: linsitinib
Targets: IGF1R; INSR
MoA: IGF-1 inhibitor
SMILES: C[C@@]1(O)CC(C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12
InchiKey: PKCDDUHJAFVJJB-FQFBAAABSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92007 BRD-K07667918 A375 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
92034 BRD-K07667918 BT20 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
92082 BRD-K07667918 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92117 BRD-K07667918 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92172 BRD-K07667918 HS578T 1.11 uM 3 h -0.25 -1.06 0.26 -0.24 -0.8 0.12
92201 BRD-K07667918 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92223 BRD-K07667918 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92263 BRD-K07667918 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92323 BRD-K07667918 MDAMB231 10 uM 3 h 0.23 0.94 0.06 -0.26 -0.88 0.25
92354 BRD-K07667918 PC3 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.42
92380 BRD-K07667918 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).