CMap Candidate Details

Structure:
CMap ID: C04858
Pert ID: BRD-K07736136
Compound Name: VX-702
Targets: MAPK14
MoA: P38 MAPK inhibitor
SMILES: NC(=O)N(c1ccc(C(N)=O)c(n1)-c1ccc(F)cc1F)c1c(F)cccc1F
InchiKey: FYSRKRZDBHOFAY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33772 BRD-K07736136 A549 10 uM 24 h 0.0 0.0 0.0 -0.49 -1.64 15.65
34037 BRD-K07736136 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34309 BRD-K07736136 HA1E 10 uM 6 h -0.24 -1.0 0.14 0.27 0.94 0.29
34551 BRD-K07736136 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34820 BRD-K07736136 HEPG2 10 uM 6 h -0.28 -1.18 0.51 -0.28 -0.94 0.39
35087 BRD-K07736136 HT29 10 uM 6 h -0.21 -0.89 0.03 0.0 0.0 0.0
35294 BRD-K07736136 MCF??7.00 10 uM 24 h -0.26 -1.07 0.27 -0.4 -1.34 1.85
35536 BRD-K07736136 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35722 BRD-K07736136 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35928 BRD-K07736136 PC3 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
36195 BRD-K07736136 PHH 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
36488 BRD-K07736136 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36945 BRD-K07736136 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
97280 BRD-K07736136 HAP1 0.66 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
97356 BRD-K07736136 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).